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KMID : 0613820090190091309
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Journal of Life Science
2009 Volume.19 No. 9 p.1309 ~ p.1313
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Sudies on the Toxicity of Benzophenone in the Developing Chick Embryo
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Yoo Min
Kim Su-Won
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Abstract
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Endocrine disruptors are chemicals which can be found in our normal daily lives. Chemicals such as bisphenol A, DDT, benzophenone and phenylphenol can be easily ingested through plastic food containers and pesticides. Endocrine disruptors can be very harmful and toxic because they disrupt the normal function of the endocrine system. It has been reported that endocrine disruptions can cause fatal strikes in the cardiovascular, reproductive, and central nervous systems, and other parts of the body. Therefore we examined if benzophenone as an endocrine disruptor inhibits development in or induces malformation of chick embryos. Chick embryos which received a single injection of benzophenone (1 ㎍/egg ～ 500 ㎍/egg) via the yolk sac at designated times (6, 9, 12, 15, 18 and 21 days after incubation) were investigated. Body weight reduction was observed in middle doses (40 ㎍/egg ～ 60 ㎍/egg). High mortality rates and teratogenic signs such as abnormal wry beak and abnormal eyeballs were seen in high doses (80 ㎍/egg ～ 500 ㎍/egg). In conclusion, it is suggested that benzophenone induces malformation of chick embryos and seriously inhibits development.
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KEYWORD
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Endocrine disruptor, chick embryo, toxicity, malformation, development
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